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P21 Polyclonal Antibody

CAT: 0763-E-AB-66357-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-66357-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Abbreviation
P21
UniProt
P38936
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant fusion protein of human p21 (NP_000380.1) .
Target
CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1; CDKN1A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21kDa
Observed Molecular Weight
21kDa
Citation 01
https://www.nature.com/articles/s41467-022-28721-x
Citation 02
https://www.mdpi.com/1574002
Citation 03
https://www.future-science.com/doi/abs/10.2144/btn-2022-0046
Isotype
IgG

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