HDAC3 Polyclonal Antibody

• Background :

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

• Abbreviation :

  HDAC3

• UniProt :

  O15379

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  A synthetic peptide of human HDAC3 (NP_003874.2) .

• Target :

  HD3; RPD3; RPD3-2; HDAC3

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC; IF

• Field of Research :

  Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Stem Cells

• Purification :

  Affinity purification

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  48kDa/49kDa

• Observed Molecular Weight :

  48kDa

• Isotype :

  IgG