TIMP2 Polyclonal Antibody

• Background:

  This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

• Abbreviation:

  TIMP2

• UniProt:

  P16035

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  A synthetic peptide of human TIMP2 (NP_003246.1) .

• Target:

  TIMP2; CSC-21K; DDC8

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IF

• Field of Research:

  Cancer; Cell Biology; Cardiovascular; Signal Transduction

• Purification:

  Affinity purification

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000; IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  24kDa

• Observed Molecular Weight:

  26kDa

• Isotype:

  IgG