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NQO1 Polyclonal Antibody

CAT: 0763-E-AB-60323-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-60323-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Abbreviation
NQO1
UniProt
P15559
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of human NQO1 (NP_000894.1) .
Target
DHQU; DIA4; DTD; NMOR1; NMORI; QR1; NQO1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
26kDa/27kDa/30kDa
Observed Molecular Weight
32kDa
Isotype
IgG

UniProtKB · P15559

NAD(P)H dehydrogenase [quinone] 1

NQO1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15559
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NQO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.6.5.2
Processing
—
Secondary accessions
B2R5Y9, B4DNM7, B7ZAD1, Q86UK1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Ligand

FADFlavoproteinNADNADP

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

Oxidoreductase

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