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CD3D Polyclonal Antibody

CAT: 0763-E-AB-60274-02Size: 120 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-60274-02Size:120 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK) . Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Abbreviation
CD3D
UniProt
P04234
Host
Rabbit
Reactivity
Human; Rat
Immunogen
Recombinant fusion protein of human CD3D (NP_000723.1) .
Target
CD3D; CD3-DELTA; IMD19; T3D
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC; IF
Field of Research
Cancer; Immunology; Stem Cells
Purification
Affinity purification
Concentration
1mg/mL
Dilution
IHC 1:50-1:100; IF 1:50-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P04234

T-cell surface glycoprotein CD3 delta chain

CD3D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04234
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD3D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8MVP6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Disease

SCID

Domain

SignalTransmembraneTransmembrane helix

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