PCBD1 Polyclonal Antibody

• Background :

  This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.

• Abbreviation :

  PCBD1

• UniProt :

  P61457

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Fusion protein of human PCBD1

• Target :

  4 alpha hydroxy tetrahydropterin dehydratase;4-alpha-hydroxy-tetrahydropterin dehydratase;6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) ;6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; DCoH; Dimerization cofactor of hepatic nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; Dimerizing cofactor for HNF1; PCBD 1; PCBD; PCBD1; PCD; Phenylalanine hydroxylase stimulating protein; Phenylalanine hydroxylase-stimulating protein; PHS; PHS; Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) ; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Pterin carbinolamine dehydratase; Pterin-4-alpha-carbinolamine dehydratase

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal transduction

• Purification :

  Antigen affinity purification

• Concentration :

  1.62 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:80-1:400

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  12 kDa

• Observed Molecular Weight :

  Refer to figures

• Isotype :

  IgG