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FDFT1 Polyclonal Antibody

CAT: 0763-E-AB-52940-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52940-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Abbreviation
FDFT1
UniProt
P37268
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human FDFT1
Target
DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT; FDFT1; FPP:FPP farnesyltransferase; SQS; Squalene synthase; Squalene synthetase; SS
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cardiovascular; Metabolism; Neuroscience
Purification
Antigen affinity purification
Concentration
1.32 mg/mL
Dilution
WB 1:1000-1:5000; IHC 1:40-1:200
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
48 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG

UniProtKB · P37268

Squalene synthase

FDFT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P37268
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FDFT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SQS, SS
EC number
2.5.1.21
Processing
—
Secondary accessions
B3KQ95, B4DJE5, B4DT56, B7Z1J3, Q96GT0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol biosynthesisCholesterol metabolismLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSterol biosynthesisSterol metabolism

Cellular component

Endoplasmic reticulumMembrane

Ligand

MagnesiumMetal-bindingNADNADP

Molecular function

Multifunctional enzymeTransferase

Domain

TransmembraneTransmembrane helix

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