SETDB1 Polyclonal Antibody

• Background :

  SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation, gene silencing, and transcriptional repression. It has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.

• Abbreviation :

  SETDB1

• UniProt :

  Q15047

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  Fusion protein of human SETDB1

• Target :

  AU022152; EC 2.1.1.43; ERG-associated protein with SET domain; ESET; H3 K9 HMTase 4; H3-K9-HMTase 4; H3-K9-HMTase4; Histone H3 K9 methyltransferase 4; Histone H3-K9 methyltransferase 4; Histone-lysine N-methyltransferase SETDB1; KG1T; KIAA0067; KMT1E; Lysine N-methyltransferase 1E; MGC90670; mKIAA0067; SET domain bifurcated 1; Set domain protein; bifurcated;1; SETB1; Setdb1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling

• Purification :

  Antigen affinity purification

• Concentration :

  1.08 mg/mL

• Dilution :

  IHC 1:50-1:300

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG