SETDB1 Polyclonal Antibody

CAT: 0866-RD252933A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD252933A-01Size:20 µL
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Background
SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation, gene silencing, and transcriptional repression. It has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
Description
This is a SETDB1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
AU022152, EC 2.1.1.43, ERG-associated protein with SET domain, ESET, H3 K9 HMTase 4, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3 K9 methyltransferase 4, Histone H3-K9 methyltransferase 4, Histone-lysine N-methyltransferase SETDB1, KG1T, KIAA0067, KMT1E, Lysine N-methylt
Swiss Prot
Q15047
Accession Number
BC009362
Reactivity
Human, Mouse
Immunogen
Fusion protein of human SETDB1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.08 mg/mL
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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