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FKBP1A Polyclonal Antibody

CAT: 0763-E-AB-52794-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52794-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Abbreviation
FKBP1A
UniProt
P62942
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human FKBP1A
Target
12 kDa FK506-binding protein;12 kDa FKBP; Calstabin 1; FK506 binding protein 1; FK506 binding protein 12; FK506 binding protein 1A (12kD) ; FK506 binding protein 1A 12kDa; FK506 binding protein 1A; FK506 binding protein T cell 12 kD; FK506 binding protein; T cell;12 kD; FK506 binding protein12; FK506-binding protein 1A; FKB1A; FKBP 12; FKBP 1A; FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP12 Exip3; FKBP12C; fkbp1a; Immunophilin FKBP12; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP1A; PKC12; PKCI2; PPIase; PPIase FKBP1A; Protein kinase C inhibitor 2; Rotamase
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Immunology
Purification
Antigen affinity purification
Concentration
0.96 mg/mL
Dilution
IHC 1:50-1:300
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P62942

Peptidyl-prolyl cis-trans isomerase FKBP1A

FKB1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P62942
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FKBP1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PPIase FKBP1A
EC number
5.2.1.8
Processing
—
Secondary accessions
D3DVW6, P20071, Q4VC47, Q6FGD9, Q6LEU3, Q9H103, Q9H566
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Cellular component

CytoplasmMembraneSarcoplasmic reticulum

Molecular function

IsomeraseRotamase

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