PCSK5 Polyclonal Antibody

CAT: 0763-E-AB-52778-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-52778-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B) .
Abbreviation
PCSK5
UniProt
Q92824
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human PCSK5
Target
FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; Pcsk5; PCSK5; Prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; Proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; Protease PC6; SPC6; Subtilisin/kexin-like protease PC5
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling
Purification
Antigen affinity purification
Concentration
0.84 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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