PHF21A Polyclonal Antibody

• Background :

  Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

• Abbreviation :

  PHF21A

• UniProt :

  Q96BD5

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  Fusion protein of human PHF21A

• Target :

  BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa) ; KIAA1696; PF21A; PHD finger protein 21A; PHF21A

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Epigenetics and Nuclear Signaling; Neuroscience

• Purification :

  Antigen affinity purification

• Concentration :

  0.7 mg/mL

• Dilution :

  IHC 1:40-1:200

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG