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KIAA0556 Polyclonal Antibody

CAT: 0763-E-AB-52101-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52101-01Size:20 µL
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Background
This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia.
Abbreviation
KIAA0556
UniProt
O60303
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human KIAA0556
Target
K0556; KIAA0556; Uncharacterized protein KIAA0556
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cell Biology
Purification
Antigen affinity purification
Concentration
1.26 mg/mL
Dilution
IHC 1:100-1:200
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · O60303

Katanin-interacting protein

KATIP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60303
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KATNIP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A7E2C2
Protein keywords

Cellular component

Cell projectionCytoplasmCytoskeleton

Disease

CiliopathyJoubert syndrome

Domain

Coiled coil

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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