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POMC Polyclonal Antibody

CAT: 0763-E-AB-40635-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-40635-02Size:100 µL
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Background
Pro-opiomelanocortin (POMC) is a precursor protein expressed in the pituitary and the brain where it is processed into several peptide hormones and neuropeptides. Among these peptides are ACTH, α- and β-MSH, β-and γ-LPH, CLIP, β-endorphin, and N-POMC. POMC is involved in hypothalamic circuits regulating feeding behavior and POMC-producing neurons promote satiety. POMC neurons are also the target of leptin and insulin for the promotion of the browning of white fat.
Abbreviation
POMC
UniProt
P01189
Host
Rabbit
Reactivity
Mouse; Rat
Immunogen
Synthetic peptide.
Target
Pro-opiomelanocortin; Corticotropin-lipotropin; NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; ACTH; CLIP; Alpha-MSH; Beta-LPH; Gamma-LPH; Beta-MSH; Beta-endorphin; Met-enkephalin
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Metabolism; Neuroscience; Signal Transduction
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
29 kDa
Observed Molecular Weight
35 kDa, 16 kDa
Isotype
IgG

UniProtKB · P01189

Pro-opiomelanocortin

COLI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01189
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POMC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
POMC
EC number
—
Processing
Precursor
Secondary accessions
P78442, Q53T23, Q9UD39, Q9UD40
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationAmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

EndorphinHormone

Disease

Obesity

Cellular component

Secreted

Domain

Signal
Product Datasheet
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