PCNA Polyclonal Antibody

CAT: 0763-E-AB-40489-01Size: 25 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-40489-01Size:25 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. It has to be loaded onto DNA in order to be able to stimulate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells.
Abbreviation
PCNA
UniProt
P12004
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of Human Proliferating cell nuclear antigen
Target
ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; MGC8367; Mutagen-sensitive 209 protein; PCNA; Pcna/cyclin; PCNA; PCNAR; Polymerase delta accessory protein; Proliferating cell nuclear antigen
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Tags and Cell Markers
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:3000-1:7000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
28 kDa
Observed Molecular Weight
35 kDa
Isotype
IgG
Product Datasheet
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