CFL1 Polyclonal Antibody

CAT: 0763-E-AB-40164-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-40164-02Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Abbreviation

Cofilin-1

UniProt

P23528

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human Homeobox protein Cofilin-1 protein

Target

18 kDa phosphoprotein; CFL 1; CFL; CFL1; COF1; Cofilin 1; Cofilin 1 non muscle; Cofilin; Cofilin non muscle isoform; Cofilin-1; epididymis secretory protein Li 15; HEL-S-15; non-muscle isoform; p18

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Cardiovascular; Neuroscience; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

17 kDa

Observed Molecular Weight

17 kDa

Isotype

IgG

UniProtKB · P23528

Cofilin-1

COF1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P23528
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CFL1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B3KUQ1, Q53Y87, Q9UCA2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Actin-binding

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembraneNucleus

Biological process

Host-virus interaction

Product Datasheet

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