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CYB5R3 Polyclonal Antibody

CAT: 0763-E-AB-19777-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-19777-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYB5R3, also named as DIA1 and B5R, belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. It plays an essential role in the mitochondrial metabolism by its contribution to cellular redox homeostasis. Overstimulation of CYB5R3 associated with lipid rafts can account for the overshot of plasma membrane-focalized superoxide anion production that triggers the entry of CGN in the irreversible phase of apoptosis.
Abbreviation
CYB5R3
UniProt
P00387
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human CYB5R3
Target
B5R; Cyb5r3; Cytochrome b5 reductase 3; Cytochrome b5 reductase; DIA1; Diaphorase 1; Diaphorase-1; NADH cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; NB5R3; OTTHUMP00000028761; OTTHUMP00000198435; OTTHUMP00000198574; OTTHUMP00000198662; OTTHUMP00000198665
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cardiovascular; Metabolism; Signal Transduction
Purification
Antigen affinity purification
Concentration
1.2 mg/mL
Dilution
IHC 1:30-1:150
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P00387

NADH-cytochrome b5 reductase 3

NB5R3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00387
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYB5R3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
B5R, Cytochrome b5 reductase
EC number
1.6.2.2
Processing
—
Secondary accessions
B1AHF2, B7Z7L3, O75675, Q8TDL8, Q8WTS8, Q9UEN4, Q9UEN5, Q9UL55, Q9UL56
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationLipoproteinMyristatePhosphoprotein

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

Cholesterol biosynthesisCholesterol metabolismLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSterol biosynthesisSterol metabolism

Cellular component

CytoplasmEndoplasmic reticulumMembraneMitochondrionMitochondrion outer membrane

Disease

Disease variant

Ligand

FADFlavoproteinNAD

Molecular function

Oxidoreductase

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