UNC13B Polyclonal Antibody

• Background:

  This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

• Abbreviation:

  UNC13B

• UniProt:

  O14795

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Fusion protein of human UNC13B

• Target:

  Hmunc13; MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B; unc-13 homolog B (C. elegans) ; UNC13; Unc13b; Unc13h2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Field of Research:

  Neuroscience; Signal transduction

• Purification:

  Antigen affinity purification

• Concentration:

  0.6 mg/mL

• Dilution:

  IHC 1:30-1:150

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG