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ITGA3 Polyclonal Antibody

CAT: 0763-E-AB-18119-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-18119-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ITGA3, also named as MSK18, CD49c, GAPB3 and FRP-2, belongs to the integrin alpha chain family. It is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. ITGA3 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. ITGA3 is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. It can be cleaved into heavy chain (840aa) and light chain (176aa) . This antibody can recognize the heavy chain.
Abbreviation
ITGA3
UniProt
P26006
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human ITGA3
Target
AA407068; Antigen identified by monoclonal J143; CD49 antigen like family member C; CD49 antigen-like family member C; CD49c; CD49c antigen; FLJ34631; FLJ34704; FRP 2; FRP-2; FRP2; Galactoprotein B3; GAP B3; GAPB3; Integrin alpha 3; Integrin alpha-3 light chain; Integrin; alpha 3 (antigen CD49C; alpha 3 subunit of VLA-3 receptor) ; ITA3; ITGA 3; Itga3; MSK18; VCA 2; VCA2; Very late activation protein 3 receptor alpha 3 subunit; VL3A; VLA 3 alpha chain; VLA 3 subunit alpha; VLA-3 subunit alpha; VLA3a
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction
Purification
Antigen affinity purification
Concentration
1.32 mg/mL
Dilution
IHC 1:40-1:200
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P26006

Integrin alpha-3

ITA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P26006
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A7E246, B7ZM80, B9EGQ1, D3DTX4, D3DTX5
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCell projectionMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantEpidermolysis bullosa

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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