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MARK1 Polyclonal Antibody

CAT: 0763-E-AB-16592-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-16592-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The microtubule matrix within a cell plays a central role in intracellular transport, cell shape during differentiation and chromosome partitioning during mitosis. During these processes, microtubules transition rapidly between stable and dynamic states. MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
Abbreviation
MARK1
UniProt
Q9P0L2
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human MARK1
Target
KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK 1; MARK; Mark1; MARK1; MGC126512; MGC126513; Serine/threonine protein kinase MARK1; Serine/threonine-protein kinase MARK1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal transduction
Purification
Affinity purification
Concentration
0.7 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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