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FZD8 Polyclonal Antibody

CAT: 0763-E-AB-16118-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-16118-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Abbreviation
FZD8
UniProt
Q9H461
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human FZD8
Target
Frizzled 8 seven transmembrane spanning receptor; frizzled 8; seven transmembrane spanning receptor; Frizzled family receptor 8; frizzled homolog 8 (Drosophila) ; Frizzled homolog 8; Frizzled-8; FZ 8; Fz-8; FZ8; FZD 8; FZD8; FZD8; hFZ 8; hFz8; HGNC4046; Homolog of Drosophila Frizzled 8
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction; Stem Cells
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q9H461

Frizzled-8

FZD8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H461
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FZD8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Fz-8, hFz8
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneGolgi apparatusMembrane

Molecular function

Developmental proteinG protein-coupled receptorReceptorTransducer

PTM

Disulfide bondGlycoproteinUbl conjugation

Domain

SignalTransmembraneTransmembrane helix

Biological process

Wnt signaling pathway

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