NQO1 Polyclonal Antibody

• Background:

  This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• Abbreviation:

  NQO1

• UniProt:

  P15559

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthetic peptide of human NQO1

• Target:

  Azoreductase; Cytochrome b 5 reductase; DHQU; DIA 4; DIA4; Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) ; Diaphorase (NADH/NADPH) ; Diaphorase 4; Dioxin inducible 1; DT diaphorase; DT-diaphorase; DTD; Menadione reductase; NAD (P) H dehydrogenase [quinone] 1; NAD (P) H dehydrogenase quinone 1; NAD (P) H menadione oxidoreductase 1 dioxin inducible; NAD (P) H quinone dehydrogenase 1; NAD (P) H: menadione oxidoreductase 1 dioxin inducible 1; NAD (P) H:menadione oxidoreductase 1; NAD (P) H:Quinone acceptor oxidoreductase type 1; NAD (P) H:quinone oxidoreductase 1; NAD (P) H:quinone oxireductase; NMOR 1; NMOR I; NMOR1; NMORI; NQO 1; NQO1; NQO1; Phylloquinone reductase; QR 1; QR1; Quinone reductase 1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cancer; Metabolism; Signal Transduction

• Purification:

  Affinity purification

• Concentration:

  0.3 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  27kDa

• Citation 01:

  https://www.mdpi.com/2072-6694/14/10/2436

• Citation 02:

  https://www.hindawi.com/journals/bmri/2021/6623328/

• Isotype:

  IgG