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CD68 Polyclonal Antibody

CAT: 0763-E-AB-15981-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-15981-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Abbreviation
CD68
UniProt
P34810
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human CD68
Target
CD 68; CD68; CD68 antigen; CD68 molecule; CD68; DKFZp686M18236; gp11; Gp110; LAMP4; Macrophage antigen CD68 (microsialin) ; MACROPHAGE ANTIGEN CD68; Macrosialin; SCARD1; Scavenger receptor class D member 1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Immunology
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P34810

Macrosialin

CD68_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P34810
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD68
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DVT4, Q53HR6, Q53XI3, Q96BI7
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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