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LRRC15 Polyclonal Antibody

CAT: 0763-E-AB-15178-04Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-15178-04Size:200 µL
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Background
Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of Alzheimer’s disease.
Abbreviation
LRRC15
UniProt
Q8TF66
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human LRRC15
Target
HLib; Leucine-rich repeat protein induced by beta-amyloid homolog; Leucine-rich repeat-containing protein 15; LIB; LRC15; LRRC15
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Immunology; Neuroscience
Purification
Affinity purification
Concentration
0.9 mg/mL
Dilution
IHC 1:50-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q8TF66

Leucine-rich repeat-containing protein 15

LRC15_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TF66
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRRC15
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q495Q6, Q7RTN7
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Glycoprotein

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

Technical term

Proteomics identificationReference proteome

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