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KARS Polyclonal Antibody

CAT: 0763-E-AB-15151-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-15151-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Abbreviation
KARS
UniProt
Q15046
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human KARS
Target
CMTRIB; DFNB89; EC 6.1.1.6; KARS 1; KARS 2; KARS; KARS1; KARS2; KIAA0070; KRS; Lysine tRNA ligase; Lysine--tRNA ligase; LysRS; Lysyl-tRNA synthetase; SYK
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q15046

Lysine--tRNA ligase

SYK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15046
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KARS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.7.-, 6.1.1.6
Processing
—
Secondary accessions
A8MSK1, D3DUK4, O14946, Q96J25, Q9HB23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Molecular function

Aminoacyl-tRNA synthetaseLigaseTransferase

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleusSecreted

Disease

Charcot-Marie-Tooth diseaseDeafnessDisease variantIntellectual disabilityNeurodegenerationNeuropathyNon-syndromic deafness

Biological process

Host-virus interactionProtein biosynthesis

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