IDH2 Polyclonal Antibody

• Background :

  Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

• Abbreviation :

  IDH2

• UniProt :

  P48735

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant protein of human IDH2

• Target :

  D2HGA2; ICD-M; IDH; IDH2; IDHM; IDHP; IDP; IDPM; Isocitrate dehydrogenase [NADP]; mitochondrial; Isocitrate dehydrogenase 2 (NADP+) ; mitochondrial; mNADP-IDH; NADP (+) -specific ICDH; Oxalosuccinate decarboxylase

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Metabolism; Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  0.4 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:100-1:300

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  51kDa

• Isotype :

  IgG