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CAST Polyclonal Antibody

CAT: 0763-E-AB-14814-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-14814-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Abbreviation
CAST
UniProt
P20810
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human CAST
Target
BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin; ICAL; MGC9402; Sperm BS 17 component; Sperm BS-17 component
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cell Biology; Neuroscience
Purification
Affinity purification
Concentration
0.7 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
77kDa
Isotype
IgG

UniProtKB · P20810

Calpastatin

ICAL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20810
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAST
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z468, G5E946, G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Palmoplantar keratoderma

Molecular function

Protease inhibitorThiol protease inhibitor

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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