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BUB1 Polyclonal Antibody

CAT: 0763-E-AB-14807-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-14807-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.
Abbreviation
BUB1
UniProt
O43683
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human BUB1
Target
Bub1; BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) ; BUB1 mitotic checkpoint serine/threonine kinase; BUB1; S. cerevisiae; homolog of; BUB1; BUB1A; BUB1L; Budding uninhibited by benzimidazoles 1 (yeast homolog) ; Budding uninhibited by benzimidazoles 1 homolog; Budding uninhibited by benzimidazoles 1; S. cerevisiae; homolog of; hBUB1; Homolog of mitotic checkpoint gene BUB1; Mitotic checkpoint gene BUB1; Mitotic checkpoint serine/threonine protein kinase BUB1; Mitotic checkpoint serine/threonine-protein kinase BUB1; Mitotic spindle checkpoint kinase; Putative serine/threonine protein kinase
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell Biology
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · O43683

Mitotic checkpoint serine/threonine-protein kinase BUB1

BUB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43683
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BUB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hBUB1
EC number
2.7.11.1
Processing
—
Secondary accessions
E9PC26, F5GXI5, O43430, O43643, O60626, Q53QE4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycleCell divisionChromosome partitionHost-virus interactionMitosis

Ligand

ATP-bindingNucleotide-binding

Cellular component

CentromereChromosomeKinetochoreNucleus

Disease

Intellectual disabilityPrimary microcephaly

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

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