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MARK1 Polyclonal Antibody

CAT: 0763-E-AB-14680-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-14680-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
Abbreviation
MARK1
UniProt
Q9P0L2
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human MARK1
Target
KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK 1; MARK; Mark1; MARK1; MGC126512; MGC126513; Serine/threonine protein kinase MARK1; Serine/threonine-protein kinase MARK1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
89kDa
Isotype
IgG

UniProtKB · Q9P0L2

Serine/threonine-protein kinase MARK1

MARK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9P0L2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MARK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1, 2.7.11.26
Processing
—
Secondary accessions
D3DTB0, D3DTB1, Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingLipid-bindingMagnesiumMetal-bindingNucleotide-binding

Disease

AutismAutism spectrum disorder

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Biological process

Wnt signaling pathway

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