CAB39 Polyclonal Antibody

• Background :

  Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .

• Abbreviation :

  CAB39

• UniProt :

  Q9Y376

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthetic peptide of human CAB39

• Target :

  Cab39; CAB39; Calcium binding protein 39; Calcium-binding protein 39; CGI 66; CGI-66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha; Protein Mo25

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Metabolism; Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  1.7 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  40kDa

• Isotype :

  IgG