ERN2 Polyclonal Antibody

• Background :

  The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein) . IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

• Abbreviation :

  ERN2

• UniProt :

  Q76MJ5

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide of human ERN2

• Target :

  IRE1b; IRE1-BETA

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  0.5 mg/mL

• Dilution :

  IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG