Connexin-26 Polyclonal Antibody

CAT: 0763-E-AB-12460-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-12460-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Abbreviation

GJB2

UniProt

P29033

Host

Rabbit

Reactivity

Human; Rat

Immunogen

Synthetic peptide of human GJB2

Target

Connexin 26; Connexin-26; Cx26; CXB2; DFNA3; DFNB1; Gap junction beta-2 protein; GJB2; HID; KID; NSRD1; PPK

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Neuroscience; Signal Transduction

Purification

Affinity purification

Concentration

2.3 mg/mL

Dilution

IHC 1:100-1:300

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · P29033

Gap junction beta-2 protein

CXB2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P29033
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GJB2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q508A5, Q508A6, Q5YLL0, Q5YLL1, Q5YLL4, Q6IPV5, Q86U88, Q96AK0, Q9H536, Q9NNY4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

Cell junctionCell membraneGap junctionMembrane

Disease

DeafnessDisease variantEctodermal dysplasiaIchthyosisNon-syndromic deafnessPalmoplantar keratoderma

PTM

Disulfide bond

Biological process

Hearing

Domain

TransmembraneTransmembrane helix

Related Products

Catalog	Name
E-CL-R0174-01	Rat CX26 -Connexin 26- CLIA Kit
E-CL-M0221	CLIA kit for Mouse CX26 (Connexin 26)
E-EL-R0260	ELISA kit for Rat CX26 (Connexin 26)
E-EL-H0830	ELISA kit for Human CX26 (Connexin 26)
E-CL-H0580-01	Human CX26 -Connexin 26- CLIA Kit
E-AB-70357-01	Connexin-40 Polyclonal Antibody
E-AB-15578-01	Connexin 47 Polyclonal Antibody
E-AB-16352-01	Connexin-45 Polyclonal Antibody
E-AB-12341-01	Connexin 47 Polyclonal Antibody
E-AB-13162-01	Connexin-45 Polyclonal Antibody

Alternative Products

Catalog	Name
JOT-AP07989-01	Connexin-26 Polyclonal Antibody
TMAB-04556-01	Anti-Connexin 26 Polyclonal Antibody
CAU35608-01	Connexin 26 (CX26) Polyclonal Antibody
ER1902-42	Connexin-26 Rabbit Polyclonal Antibody
70R-49792	Connexin 26 antibody
144381	Connexin 26 (Connexin-26)