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MAP3K12 Polyclonal Antibody

CAT: 0763-E-AB-10631-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10631-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Abbreviation
MAP3K12
UniProt
Q12852
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human MAP3K12
Target
Dlk; Dual leucine zipper bearing kinase; Dual leucine zipper kinase DLK; Leucine-zipper protein kinase; M3K12; Map3k12; MAPK-upstream kinase; MEKK12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; Protein kinase MUK; ZPK; ZPKP1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal Transduction
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q12852

Mitogen-activated protein kinase kinase kinase 12

M3K12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12852
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B3KSS9, G3V1Y2, Q86VQ5, Q8WY25
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Domain

Repeat

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