CDKN2AIP Polyclonal Antibody

• Background :

  CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame) -dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

• Abbreviation :

  CDKN2AIP

• UniProt :

  Q9NXV6

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Recombinant protein of human CDKN2AIP

• Target :

  Calcium response factor; CARF; CARF; CDKN2A interacting protein; CDKN2A-interacting protein; Cdkn2aip; collaborates/cooperates with ARF (alternate reading frame) protein; Collaborator of ARF; FLJ20036

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cancer; Cell Biology; Epigenetics and Nuclear Signaling

• Purification :

  Affinity purification

• Concentration :

  0.3 mg/mL

• Dilution :

  IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG