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Cathepsin L Polyclonal Antibody

CAT: 0763-E-AB-10211-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10211-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
Abbreviation
CTSL
UniProt
P07711
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human CTSL
Target
Cathepsin L;1 b; Cathepsin L1; Cathepsin L1 light chain; CathepsinL; CATL; CATL1; cb15; CTSL; CTSL1; ctsl1b; FLJ31037; hgg1; Major excreted protein; MEP; MGC123162; wu:fb30g09
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P07711

Procathepsin L

CATL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07711
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTSL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.15
Processing
Precursor
Secondary accessions
Q6IAV1, Q96QJ0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative initiation

Cellular component

Cell membraneCytoplasmic vesicleLysosomeMembraneNucleusSecreted

PTM

Disulfide bondGlycoproteinZymogen

Biological process

Host-virus interaction

Molecular function

HydrolaseProteaseThiol protease

Domain

Signal

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