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Cathepsin B Polyclonal Antibody

CAT: 0763-E-AB-10208-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10208-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP) . Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Abbreviation
CTSB
UniProt
P07858
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human CTSB
Target
Amyloid precursor protein secretase; APP secretase; APPS; CATB; Cathepsin B heavy chain; Cathepsin B1; CathepsinB; CPSB; CTSB; cysteine protease; OTTHUMP00000116009; OTTHUMP00000229510; OTTHUMP00000229511; OTTHUMP00000229512; OTTHUMP00000229514; OTTHUMP00000229515; OTTHUMP00000229516; Preprocathepsin B
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
0.8 mg/mL
Dilution
IHC 1:150-1:500
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P07858

Cathepsin B

CATB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07858
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTSB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.1
Processing
Precursor
Secondary accessions
B3KQR5, B3KRR5, Q503A6, Q96D87
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinZymogen

Cellular component

Cell membraneLysosomeMembraneSecreted

Molecular function

HydrolaseProteaseThiol protease

Domain

Signal

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