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L 152804

CAT: 0804-HY-107734-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107734-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].
CAS Number
6508-43-6
UNSPSC
12352005
Hazard Statement
H301, H410
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-152804.html
Purity
99.89
Solubility
DMSO : ≥ 125 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(CC(C)(C)C1)OC3=CC=CC=C3C2C4C(CC(C)(C)CC4=O)=O
Molecular Formula
C23H26O4
Molecular Weight
366.45
Precautions
H301, H410
References & Citations
[1]Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272 (1) :169-73.|[2]Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71 (2) :602-8. Epub 2006 Nov 14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y5 receptor

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Alternative Products

CatalogName
MBS5755057L 152804
1382/10L-152804
A19834-25L 152804 25mg
A19834-50L 152804 50mg
A19834-200L 152804 200mg
A19834-10L 152804 10mg
A19834-100L 152804 100mg
A19834-5L 152804 5mg
A19834-10mM-DL 152804 10mM * 1mL in DMSO

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