FITC Anti-Mouse CD279/PD-1 Antibody[29F.1A12]

• Background:

  CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

• Abbreviation:

  CD279

• Gene ID:

  18566

• UniProt:

  Q02242

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  Programmed Death-1; PD-1

• Clonality:

  Monoclonal

• Clone:

  29F.1A12

• Conjugation:

  FITC

• Applications:

  FCM

• Field of Research:

  Cancer Biomarkers; Immunology; Inhibitory Molecules

• Concentration:

  0.5 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Recommended Usage:

  6

• Isotype:

  Rat IgG2a, κ