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PD-1/CD279 Polyclonal Antibody

CAT: 0763-E-AB-70227-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-70227-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .
Abbreviation
PD-1/CD279
UniProt
Q02242
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant protein corresponding to Mouse CD279/PD-1
Target
CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Immunology
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
32kDa
Observed Molecular Weight
55kDa
Isotype
IgG

UniProtKB · Q02242

Programmed cell death protein 1

PDCD1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q02242
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Pdcd1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
Protein PD-1, mPD-1
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureReference proteome

Biological process

Adaptive immunityApoptosisImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix
Product Datasheet
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