Products for Research Use Only

RecombinantBDNF, Human

CAT: 0013-GTR18990445-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990445-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BDNF, also known as brain-derived neurotrophic factor and abrineurin, is a neurotrophin belonging to the NGF-beta family. It is expressed highly in the brain, and moderately in the heart, lung, skeletal muscle and placenta. BDNF signals through its high affinity receptor gp145/trkB to exert neurotrophic properties. It has been shown to be involved in the survival and differentiation of both the central and peripheral nervous system. Specifically, BDNF regulates synaptic transmission, axonal growth and path-finding, as well as dendritic growth and morphology.
Product Name Alternative
Brain-derived neurotrophic factor, abrineurin
Source
CHO
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50<4μg/ml, measured in a bioassay using C6 cells.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
12-14kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human BDNF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human BDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
HSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQC RTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR