Products for Research Use Only
RegisterLogin

RecombinantPDGF-BB, Rat

CAT: 0013-GTR18990464-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18990464-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo, PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets.Recombinant rat Platelet-Derived Growth Factor-BB (rrPDGF-BB) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 110 amino acids each. A fully biologically active molecule, rrPDGF-BB has a molecular mass of 24.6 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
PDGF
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE analysis.
Bioactivity
ED50 5 x 10ˆ5 units/mg.
Form
Lyophilized after extensive dialysis against 20 mM acetic acid.
Molecular Weight
24.6 kDa, observed by non-reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant rat Platelet-Derived Growth Factor-BB (rrPDGF-BB) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrPDGF-BB remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in 20 mM acetic acid at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against 20 mM acetic acid.
AA Sequence
MSLGSLAAA EPAVIAECKT RTEVFQISRN LIDRTNANFL VWPPCVEVQR CSGCCNNRNV QCRASQVQMR PVQVRKIEIV RKKPVFKKAT VTLEDHLACK CETVVTPRPV T

Related Products

CatalogName
GTR18990465-01RecombinantPDGF-BB, Mouse
GTR18990198RecombinantPDGF-BB, Human (P.pastoris-expressed)
GTR18990466-01RecombinantPDGF-AA, Mouse
GTR18990259-01RecombinantPDGF-DD, Human
GTR18990216-01RecombinantPDGF-CC, Human
GTR18906273-01Rat PDGF-BB protein
GTR18853638-01Rat Platelet Derived Growth Factor BB (PDGF-BB) ELISA Kit
GTR18818603-01Rat PDGF-BB ELISA Kit
GTR18806653-01Rat PDGF-BB ELISA Kit
GTR18798719Rat PDGF-BB ELISA Kit

Alternative Products

CatalogName
BK0152RecombinantPDGF-BB,Mouse
BK0152-01RecombinantPDGF-BB, Mouse
BK0153RecombinantPDGF-BB,Rat
BK0153-01RecombinantPDGF-BB, Rat
BK0343RecombinantPDGF-BB, Human (P.pastoris-expressed)
BK0343RecombinantPDGF-BB,Human(P.pastoris-expressed)
BK0327RecombinantPDGF-CC,Human
BK0327-01RecombinantPDGF-CC, Human
BK0151-01RecombinantPDGF-AA, Mouse
BK0151RecombinantPDGF-AA,Mouse

Popular Products