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Endo-S-cGAFMP

CAT: 0804-HY-176256Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176256Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endo-S-cGAFMP (Compound 3) is a STING agonist. endo-S-cGAFMP induces the production of interferon regulatory factors and proinflammatory cytokines by activating the cGAS-STING pathway, thereby enhancing innate and adaptive immune responses. endo-S-cGAFMP has potent immunostimulatory capacity in THP1 monocytes and RAW macrophages (EC50 values of 2.45 μM and 5.54 μM, respectively) . endo-S-cGAFMP has significant antitumor activity. endo-S-cGAFMP can be used as a potential cancer immunotherapeutic agent, especially for studies of systemic administration[1].
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
F[C@@H]1[C@H](O2)[C@@H](CSP(O)(O[C@@H]3[C@H](O)[C@@H](COP2(O)=O)O[C@H]3N(C=N4)C5=C4C(NC(N)=N5)=O)=O)O[C@H]1N6C=NC7=C6N=CN=C7N
Molecular Formula
C20H23FN10O11P2S
Molecular Weight
692.47
References & Citations
[1]Simpa K. Yeboah, et al. 5′-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously. ACS Bio & Med Chem Au 0, 0, pp.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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