DAMGO (TFA)

• Description :

  DAMGO TFA is a μ-opioid receptor (μ-OPR) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].

• UNSPSC :

  12352209

• Target :

  Opioid Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/damgo-tfa.html

• Concentration :

  10mM

• Purity :

  99.52

• Solubility :

  H2O : ≥ 100 mg/mL

• Smiles :

  OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1.OC(C(F)(F)F)=O

• Molecular Formula :

  C28H36F3N5O8

• Molecular Weight :

  627.61

• References & Citations :

  [1]FEBS Lett. 1995 Jan 2;357 (1) :93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.|[2]Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12 (6) :492-500.|[3] Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212 (2) :83-6.|[4]Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53 (3) :277-285.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  μ Opioid Receptor/MOR

• Citation 01 :

  Cell. 2022 Nov 10;185 (23) :4361-4375.e19.|Cell. 2023 Jan 19;186 (2) :413-427.e17.|Alzheimers Res Ther. 2025 Feb 1;17 (1) :35.|Aquaculture. 2025 Apr 15.|bioRxiv. 2022 Jul 11.|bioRxiv. 2024 Jul 26:2024.07.26.605282.|Cell Rep Methods. 2025 May 19;5 (5) :101051.|Nature. 2025 Dec;648 (8094) :755-763.|Seoul National University. 2024 Feb.

• CAS Number :

  [950492-85-0]