Theophylline-d6

Theophylline-d6

• CAS Number: 117490-39-8
• UNSPSC Description: Theophylline-d6 is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.
• Target Antigen: Adenosine Receptor; Autophagy; Endogenous Metabolite; Phosphodiesterase (PDE)
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;GPCR/G Protein;Metabolic Enzyme/Protease
• Field of Research: Cancer
• Purity: 99.90
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C([2H])([2H])[2H])N(C([2H])([2H])[2H])C2=C(N=CN2)C1=O
• Molecular Weight: 186.20
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Deree J, et al. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8.|[3]Marques LJ, et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999 Feb;159(2):508-11.|[4]Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported