Theophylline (monohydrate)

• Description:

  Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

• Product Name Alternative:

  1,3-Dimethylxanthine (monohydrate) ; Theo-24 (monohydrate)

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H311, H330

• Target:

  Adenosine Receptor; Apoptosis; Endogenous Metabolite; HDAC; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/theophylline-monohydrate.html

• Purity:

  99.85

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N(C)C(N1C)=O)N=CN2.O

• Molecular Formula:

  C7H10N4O3

• Molecular Weight:

  198.18

• Precautions:

  H301, H311, H330

• References & Citations:

  [1]Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8 (4) :637-42.|[2]Chung IY, et, al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000 Aug 1;203 (2) :95-102.|[3]Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364 (6) :558-61.|[4]Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99 (13) :8921-6.|[5]Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188 (8) :901-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite; IL-10; IL-6; PDE3

• CAS Number:

  [5967-84-0]