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Theophylline-d3

CAT: 0804-HY-B0809S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0809S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Theophylline-d3 is deuterated labeled Theophylline. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
CAS Number
65566-68-9
Product Name Alternative
1,3-Dimethylxanthine-d3; Theo-24-d3
UNSPSC
12352005
Target
Adenosine Receptor; Apoptosis; Endogenous Metabolite; HDAC; Interleukin Related; Isotope-Labeled Compounds; Phosphodiesterase (PDE) ; TNF Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(N1C([2H])([2H])[2H])N(C)C2=C(N=CN2)C1=O
Molecular Formula
C7H5D3N4O2
Molecular Weight
183.18
References & Citations
[1]Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8 (4) :637-42.|[2]Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7 (5) :371-5.|[3]Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364 (6) :558-61.|[4]Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99 (13) :8921-6.|[5]Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188 (8) :901-6.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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