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CPPHA

CAT: 0804-HY-14612-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14612-01Size:5 mg
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Description
CPPHA is potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor) . CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders[1][2].
CAS Number
693288-97-0
UNSPSC
12352005
Hazard Statement
H400, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CPPHA.html
Purity
98.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C(C2=CC=CC=C21)=O)CC3=CC(Cl)=CC=C3NC(C4=CC=CC=C4O)=O
Molecular Formula
C22H15ClN2O4
Molecular Weight
406.82
Precautions
H400, H410
References & Citations
[1]Liu F, et al. The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices. Eur J Pharmacol. 2006 May 1;536 (3) :262-8.|[2]O'Brien JA, et al. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther. 2004 May;309 (2) :568-77.|[3]Zhang Y, et al. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J Pharmacol Exp Ther. 2005 Dec;315 (3) :1212-9.|[4]N-{4-Chloro-2-[ (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol. 2008 Mar;73 (3) :909-18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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CatalogName
BC171188-01CPPHA
A15053-100CPPHA 100mg
A15053-50CPPHA 50mg
A15053-10CPPHA 10mg
A15053-5CPPHA 5mg
A15053-10mM-DCPPHA 10mM * 1mL in DMSO

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