Anti-Importin subunit alpha-6 KPNA5 Antibody

• Description:

  Boster Bio Anti-Importin subunit alpha-6 KPNA5 Antibody catalog # A09441-2. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Importin subunit alpha-6; Karyopherin subunit alpha-5; KPNA5;

• Gene Name:

  KPNA5

• UniProt:

  O15131

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant full length Human KPNA5.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Testis.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:2000

• Form:

  Liquid

• Function:

  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

• Molecular Weight:

  60349 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Importin subunit alpha-6

• Subcellular Location:

  Cytoplasm.

• Protein Name:

  Importin subunit alpha-6