Anti-Splicing factor 3B subunit 3 SF3B3 Antibody

• Description:

  Boster Bio Anti-Splicing factor 3B subunit 3 SF3B3 Antibody catalog # A08240-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Splicing factor 3B subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130

• Gene Name:

  SF3B3

• UniProt:

  Q15393

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human SF3B3.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166) . SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937) . May also be involved in the assembly of the 'E' complex (PubMed:10882114) . Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077) .

• Molecular Weight:

  135577 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Splicing factor 3B subunit 3

• Subcellular Location:

  Nucleus

• Protein Name:

  Splicing factor 3B subunit 3