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Anti-LAMTOR5 Antibody

CAT: 0519-A08205Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A08205Size:100 µL
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Description
Boster Bio Anti-LAMTOR5 Antibody catalog # A08205. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Ragulator complex protein LAMTOR5; Hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; LAMTOR5; HBXIP, XIP;
Gene Name
LAMTOR5
UniProt
O43504
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human LAMTOR5 (NP_006393.2) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Molecular Weight
9614 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Ragulator complex protein LAMTOR5
Subcellular Location
Cytoplasm. Lysosome.
Protein Name
Ragulator complex protein LAMTOR5

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